4E-BP1 (EP352) Rabbit Monoclonal Antibody

The eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), also known as eIF4E-BP1, is a translation repressor inhibiting protein synthesis that sequester the mRNA cap-binding protein eIF4E. The Akt/mTOR/4E-BP1 pathway is considered to be a central regulator of protein synthesis.

This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. Over expression of total and phosphorylated 4E-BP1 has been associated with tumor progression in carcinomas of the breast, ovary, prostate and liver.

Specifications

• Dilution Range: 1:100 – 1:200*