5T4 (EP347) Rabbit Monoclonal Antibody

5T4 oncofetal antigen, also known as trophoblast glycoprotein (TPBG) is a 72-kDa membrane glycoprotein. While its specific function is unknown, 5T4 expression has been shown to influence adhesion, cytoskeletal organization and cell motility. Placental syncytiotrophoblasts highly express the 5T4 antigen.

In contrast, 5T4 (EP347) Rabbit Monoclonal Antibody expression has been reported in approximately 85% of colorectal and 81% of gastric carcinomas; expression in carcinomas of the bronchus, breast, cervix, endometrium, pancreas and ovary have also been reported. Presence of 5T4 in malignant cells is associated with advanced disease and poorer overall survival. Recent studies have shown that the 5T4 antigen is expressed on proliferating tumor-initiating cells (cancer stem cells) and associated with the epithelial-mesenchymal transition.

Due to its restricted expression and association with worse clinical outcome, 5T4 is a viable therapeutic target. Several vaccines, antibody-targeted immunotherapies and antibody-drug conjugates against 5T4 are currently under development.

Specifications

• Dilution Range: 1:100 – 1:200*