C4d Rabbit Polyclonal Antibody

Acute humoral rejection is mediated by antibodies to the donor endothelium that activate the classical complement pathway.^1-3 This leads to a number of split products of complement proteins. C4d is a fragment of C 4 complement released during activation of the classic complement pathway by the antigen antibody complex.³ C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response.^3,6 C4d can be a useful tool for indicating acute renal allograft rejection.^1-6

Specifications

• Reactivity: paraffin
• Visualization: cytoplasmic, membranous
• Control: lymph node, tonsil, acute rejected kidney transplant
• Dilution Range: 1:50-1:200*