ACSL4 (EP386) Rabbit Monoclonal Antibody

The long-chain-fatty-acid–CoA ligase 4 (ACSL4) is a fatty acid synthetase that uses arachidonic and eicosapentaenoic acids as substrates.  Inhibitor studies also indicate ACSL4 involvement of triacylglyercol synthesis in the liver.  ACSL4 is essential for normal development and reproduction, and its mRNA is highly expressed in placenta, brain, testis, ovary, spleen and adrenal gland.  Intracellularly, ACSL4 is localized in the cytoplasm with peroxisomes and mitochondria.  Since altered expression of lipid metabolic enzymes is a feature of a variety of cancers, several in vitro and in vivo studies demonstrated inhibition of the ACSL4 in inhibiting growth and survival of cancer cells.  ACSL4 is overexpressed in colon and liver carcinoma specimens compared against benign colon and liver.  Furthermore,  ACSL4 was reported to be inversely correlated with sex steroid receptor (ER and AR) expression in breast and prostate carcinomas.  The inverse correlation was indicative of resistance to hormone-based treatment in these tumors.  ACSL4 expression was highest in triple-negative breast cancer cell lines and tumors that lacked AR expression. In ER-negative breast tumors, high ACSL4 expression predicted a shorter time to distant metastasis.

Specifications

• Dilution Range: 1:60*