LEGEND MAX™ Human IL-36γ ELISA Kit with Pre-coated Plates

The IL-1 family of cytokines comprised of 11 members, including the recently renamed IL-36 cytokines: IL-36α, β and γ, previously known as IL-1F6, IL-1F8 and IL-1F9 respectively. IL-36γ signals through the IL-1 receptor family members IL-1Rrp2 and IL-1RAcP and can activate downstream MAP kinases and the transcription factor NF-kB. IL-36γ is synthesized without a signal peptide and its secretion mechanism is unclear. Like other IL-36 cytokines, it has been demonstrated that N-terminal processing of IL-36γ can significantly increase its biological activity. However, the enzymes responsible for this processing remain unknown.

IL-36γ is mainly expressed by epithelial cells. It is also associated with skin disorders such as respiratory papillpmatosis, psoriasis, hyperkeratosis and Aspergillus fumigatus infection.

The BioLegend LEGEND MAX™ Human IL-36γ Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) kit includes a 96-well strip plate that is pre-coated with a mouse monoclonal anti-human IL-36γ capture antibody. The detection antibody is a biotinylated polyclonal rabbit anti-human IL-36γ antibody. This kit is specifically designed for the accurate quantitation of human IL-36γ from cell culture supernatant, serum, plasma, and other biological fluids. It is analytically validated with ready-to-use reagents.