LEGEND MAX™ Human CXCL11 (I-TAC) ELISA Kit with Pre-coated Plates 5 Pre-coated Plates

CXCL11 (Chemokine (C-X-C motif) ligand 11), also known as Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9), is a small cytokine belonging to the CXC chemokine family that lacks the ELR (Glutamate-Leucine-Arginine) tripeptide motif. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate expression levels in thymus, spleen, and lung and low expression levels were in small intestine, placenta, and prostate. CXCL11 is functionally and structurally related to CXCL9 and CXCL10. CXCL11, together with CXCL9 and CXCL10, specifically binds to the G protein-coupled receptor CXCR3 and is involved in chemotaxis of immune cells and angiogenesis. Of all three CXCR3 agonists, CXCL11 is the most potent and efficacious, featuring the highest affinity for CXCR3. Expression of both CXCR3 and CXCL11 by the Th1-associated cytokine IFNγ creates an amplification loop of cell-mediated immune response between Th1 cells. CXCR7 has been identified as an alternative receptor for CXCL11 and is involved in growth, survival, and adhesion of tumor cells.

The LEGEND MAX™ Human CXCL11 (I-TAC) ELISA kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with a mouse monoclonal anti-human CXCL11 antibody. The Detection Antibody is a biotinylated mouse monoclonal anti-human CXCL11 antibody. This kit is specifically designed for the accurate quantitation of human CXCL11 (I-TAC) from cell culture supernatant, serum, heparin plasma, EDTA plasma, and other biological fluids. This kit is analytically validated with ready-to-use-reagents.