LEGEND MAX™ Human CCL5 (RANTES) ELISA Kit with Pre-coated Plates 1 Pre-coated Plate

CCL5, also known as RANTES, is a member of the CC family of chemokines. The precursor of CCL5 contains 91 amino acids, with an N-terminal signal peptide of 23 amino acids which is cleaved to generate the 68 amino acids mature protein (7.8 kD). Human mature CCL5 shares 82% – 90% amino acid seqeuence identity with equine, porcine, bovine, mouse, rat and canine CCL5.

CCL5 is expressed by T cells and monocytes/macrophages. It plays an active role in recruiting leukocytes into inflammatory sites through receptors CCR1, CCR3, CCR4, and CCR5. CCL5 induces the proliferation and activation of certain natural killer (NK) cells. It also inhibits HIV-1 entry and infection. In addition, CCL5 plays a crucial role in the migration and metastasis of cancer cells. Increased CCL5 levels are found in melanoma, breast, cervical, prostate, gastric, and pancreatic cancers.

BioLegend’s LEGEND MAX™ Human CCL5 (RANTES) ELISA Kit is a Sandwich Enzyme-Linked Immunosorbent Assay (ELISA) with a 96-well strip plate that is pre-coated with an antibody specific for human CCL5. This kit is specifically designed for the accurate quantitation of human CCL5 from cell culture supernatant, serum, plasma, and other biological fluids. This kit is analytically validated with ready-to-use reagents.